≡

Interleukin 31 Receptor A (IL31RA)

[Edit]

CRL; CRL3; GLM-R; GLMR; GPL; IL-31RA; ZcytoR17; •Cytokine receptor-like 3; Gp130-like monocyte receptor

Interleukin 31 Receptor A (IL31RA)
CCC E763
HGNC 18969
MGI 2180511
PubMed 19690585
RGD 1586478
UniProt Q8NI17
Wiki IL31RA
IL31RA is related to gp130, the common receptor subunit for IL6-type cytokines. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells.The extracellular region of GLMR has a 19-residue signal peptide, followed by a cytokine receptor homology domain, which contains 2 pairs of conserved cysteines and a WSDWS signature motif, and 3 modules with homology to fibronectin type III domains. The intracellular region of GLMR is connected to a single transmembrane domain and contains a box-1 motif, which is probably involved in association with JAK family tyrosine kinases, and 4 tyrosine residues that may serve as docking sites for molecules with SH2 domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE763Hu01 Recombinant Interleukin 31 Receptor A (IL31RA) Positive Control; Immunogen; SDS-PAGE; WB.
RPE763Hu02 Recombinant Interleukin 31 Receptor A (IL31RA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE763Hu01 Polyclonal Antibody to Interleukin 31 Receptor A (IL31RA) WB,ICC/IF
Assay Kits n/a CLIA Kit for Interleukin 31 Receptor A (IL31RA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 31 Receptor A (IL31RA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 31 Receptor A (IL31RA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 31 Receptor A (IL31RA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 31 Receptor A (IL31RA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 31 Receptor A (IL31RA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 31 Receptor A (IL31RA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 31 Receptor A (IL31RA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 31 Receptor A (IL31RA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 31 Receptor A (IL31RA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 31 Receptor A (IL31RA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 31 Receptor A (IL31RA) ELISA Kit Customized Service Offer
  1. "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5."J. Biol. Chem. 277:16831-16836(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." Nat. Immunol. 5:752-760(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor."J. Biol. Chem. 278:49850-49859(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling."Eur. Cytokine Netw. 15:291-302(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the signaling capacities of the novel gp130-like cytokine receptor."J. Biol. Chem. 279:36112-36120(2004) [PubMed] [Europe PMC] [Abstract]
  10. "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis."Eur. J. Hum. Genet. 18:26-32(2010) [PubMed] [Europe PMC] [Abstract]