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Importin 11 (IPO11)

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RanBP11; SLRN; Ran-binding protein 11

Importin 11 (IPO11)
CCC E757
HGNC 20628
MGI 2442377
PubMed 23216389
RGD 1311133
UniProt Q9UI26
Wiki IPO11
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors that mediate nucleocytoplasmic transport of protein and RNA cargoes .The deduced 975-amino acid protein shares 24% amino acid identity with S. cerevisiae Lph2 protein.
IPO11 increased nuclear accumulation of RPL12 in a RAN-dependent manner, and overexpression of an IPO11 mutant lacking the RAN-binding domain did not increase nuclear accumulation of RPL12. In vitro binding assay showed that IPO11 did not bind RPL23A, and transient transfection assay showed that importin-beta and IPO5 (RANBP5) had no effect on nucleocytoplasmic distribution of RPL12, indicating that IPO11 is a specific nuclear import receptor for RPL12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE757Hu01 Recombinant Importin 11 (IPO11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Importin 11 (IPO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 11 (IPO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 11 (IPO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 11 (IPO11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 11 (IPO11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 11 (IPO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 11 (IPO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 11 (IPO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 11 (IPO11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 11 (IPO11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 11 (IPO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 11 (IPO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 11 (IPO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 11 (IPO11) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2."EMBO J. 19:5502-5513(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]