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Karyopherin Alpha 4 (KPNa4)

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IPOA3; QIP1; SRP3; Importin Alpha 3

Karyopherin Alpha 4 (KPNa4)
CCC E749
HGNC 6397
MGI 1100848
PubMed 23132271
RGD 1311483
UniProt O00629
Wiki KPNA4
Karyopherin Alpha 4 shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
The predicted 521-amino acid QIP1 protein contains the conserved N-terminal binding site for karyopherin-beta and a series of 7 degenerate 'armadillo' repeats, which are 42-amino acid motifs implicated in protein-protein interactions. Human QIP1 has 50% amino acid identity with human KPNA2, 49% with Xenopus importin-alpha, 47% with human KPNA1 , and 46% with S. cerevisiae Srp1. The authors demonstrated that QIP1 interacted with the NLSs of DNA helicase Q1 and SV40 T antigen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE749Hu01 Recombinant Karyopherin Alpha 4 (KPNa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 4 (KPNa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 4 (KPNa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 4 (KPNa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 4 (KPNa4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 4 (KPNa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 4 (KPNa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 4 (KPNa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 4 (KPNa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 4 (KPNa4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 4 (KPNa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 4 (KPNa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 4 (KPNa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 4 (KPNa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 4 (KPNa4) ELISA Kit Customized Service Offer
  1. "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL."Biochem. Biophys. Res. Commun. 234:48-53(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family."FEBS Lett. 417:104-108(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway."J. Virol. 77:3734-3748(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Importin alpha protein acts as a negative regulator for Snail protein nuclear import."J. Biol. Chem. 286:15126-15131(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]