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Tubulin Folding Cofactor C (TBCC)

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TBC-C; CFC; Tubulin Specific Chaperone C

Tubulin Folding Cofactor C (TBCC)
CCC E726
HGNC 11580
MGI 1919976
PubMed 19631545
RGD 1306756
UniProt Q15814
Microtubules are essential and ubiquitous elements of the cytoskeleton. Their filamentous arrays contribute to an impressive diversity of biologic functions that include cell division, intracellular transport, and the maintenance of cellular architecture.
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Folding Cofactor C (TBCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Folding Cofactor C (TBCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Folding Cofactor C (TBCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Folding Cofactor C (TBCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Folding Cofactor C (TBCC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Folding Cofactor C (TBCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Folding Cofactor C (TBCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Folding Cofactor C (TBCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Folding Cofactor C (TBCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Folding Cofactor C (TBCC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Folding Cofactor C (TBCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Folding Cofactor C (TBCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Folding Cofactor C (TBCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Folding Cofactor C (TBCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Folding Cofactor C (TBCC) ELISA Kit Customized Service Offer
  1. "Pathway leading to correctly folded beta-tubulin."Cell 86:287-296(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C."J. Biol. Chem. 277:14629-14634(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3."Hum. Mol. Genet. 11:3065-3074(2002) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the C-terminal region in human tubulin folding cofactor C."Submitted (APR-2008) to the PDB data bank
  14. "Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia."Am. J. Hum. Genet. 89:745-750(2011) [PubMed] [Europe PMC] [Abstract]