Tubulin Folding Cofactor B (TBCB)
[Edit]TBC-B; CG22; CKAP1; CKAPI; Cytoskeleton-Associated Protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B
The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. Cytoskeletal activity is modulated by many cytoskeleton-associated proteins (CAPs). One group of CAPs is characterized by a highly conserved glycine motif, the CAP-GLY domain, which may contribute to its association with microtubules. Members of the group of CAPs include dynactin, the dynein-associated protein. Watanabe et al. (1996) isolated a novel member of this family, which they called CKAPI (for cytoskeleton-associated protein I, glycine motif). The cDNA was isolated from a human fetal-brain cDNA library and found to contain an open reading frame of 579 nucleotides encoding a 193-amino acid polypeptide. Three transcripts of different sizes were expressed in all tissues examined.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE725Hu01 | Recombinant Tubulin Folding Cofactor B (TBCB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor B (TBCB) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tubulin Folding Cofactor B (TBCB) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE725Mu01 | Recombinant Tubulin Folding Cofactor B (TBCB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor B (TBCB) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tubulin Folding Cofactor B (TBCB) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Tubulin Folding Cofactor B (TBCB) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor B (TBCB) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tubulin Folding Cofactor B (TBCB) | ELISA Kit Customized Service Offer |
- "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors."J. Cell Biol. 138:821-832(1997) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-Gly domain."Cytogenet. Cell Genet. 72:208-211(1996) [PubMed] [Europe PMC] [Abstract]
- "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
- "Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway."Curr. Biol. 15:2050-2055(2005) [PubMed] [Europe PMC] [Abstract]
- "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B."Mol. Cell. Biol. 25:3726-3736(2005) [PubMed] [Europe PMC] [Abstract]
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]