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Tubulin Beta 4 (TUBb4)

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TUBB5; Tubulin 5 beta

Tubulin Beta 4 (TUBb4)
CCC E713
HGNC 20774
MGI 107848
PubMed 23595291
UniProt P04350
Wiki TUBB4
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and β-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. Hall et al. (1983) identified a beta-tubulin gene that they designated 5-beta. The 5-beta gene was expressed as a 2.6-kb transcript on Northern blots of HeLa cell mRNA. Lee et al. (1984) reported that the 5-beta sequence encodes a predicted 445-amino acid protein. Using Northern analysis, they determined that 5-beta is expressed in fetal brain, but not in cell lines derived from various other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Beta 4 (TUBb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Beta 4 (TUBb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Beta 4 (TUBb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Beta 4 (TUBb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Beta 4 (TUBb4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Beta 4 (TUBb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Beta 4 (TUBb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Beta 4 (TUBb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Beta 4 (TUBb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Beta 4 (TUBb4) ELISA Kit Customized Service Offer
  1. "Sequence of an expressed human beta-tubulin gene containing ten Alu family members."Nucleic Acids Res. 12:5823-5836(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type."Biochem. Biophys. Res. Commun. 219:238-242(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."Cell 137:1076-1087(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Tumoral and tissue-specific expression of the major human beta-tubulin isotypes."Cytoskeleton 67:214-223(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "A de novo mutation in the beta-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum." Am. J. Hum. Genet. 92:767-773(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia."Ann. Neurol. 73:546-553(2013) [PubMed] [Europe PMC] [Abstract]