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FK506 Binding Protein 10 (FKBP10)

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FKBP65; hFKBP65; Rotamase; 65 kDa FK506-binding protein; Immunophilin FKBP65; Peptidyl-prolyl cis-trans isomerase FKBP10

FK506 Binding Protein 10 (FKBP10)
CCC E680
HGNC 18169
MGI 104769
PubMed 21567934
RGD 1549751
UniProt Q96AY3
Wiki FKBP10
FK506 Binding Protein 10 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.mouse Fkbp10 is contained within the lumen of the endoplasmic reticulum. Western blot analysis detected expression in 12-day-old mouse aorta, brain, kidney, and lung; no or barely detectable expression was found in adult tissues. Immunolocalization of Fkbp10 in developing lung revealed staining of vascular and airway smooth muscle cells. the human and mouse protein sequences are identical with the exception of a valine-24 addition within the signal sequence of the human protein. Both contain 4 consecutive PPIase domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE680Hu01 Recombinant FK506 Binding Protein 10 (FKBP10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE680Hu01 Polyclonal Antibody to FK506 Binding Protein 10 (FKBP10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 10 (FKBP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 10 (FKBP10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE680Mu01 Recombinant FK506 Binding Protein 10 (FKBP10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE680Mu01 Polyclonal Antibody to FK506 Binding Protein 10 (FKBP10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 10 (FKBP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 10 (FKBP10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 10 (FKBP10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 10 (FKBP10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 10 (FKBP10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 10 (FKBP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 10 (FKBP10) ELISA Kit Customized Service Offer
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  10. "Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta." Am. J. Hum. Genet. 86:551-559(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome."J. Bone Miner. Res. 26:666-672(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen." Hum. Mol. Genet. 22:1-17(2013) [PubMed] [Europe PMC] [Abstract]