Fascin 2 (FSCN2)

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RFSN; RP30; Actin-Bundling Protein,Retinal,Strongylocentrotus Purpuratus

Fascin 2 (FSCN2)
Fascin-2 is a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.FSCN2 shares 56% amino acid identity with FSCN1 and 94% identity with bovine retinal fascin. The largest block of conserved sequence between human and bovine FSCN2 includes a putative phosphorylation site at ser39. FSCN2 also shares significant similarity with several other vertebrate and invertebrate fascins. Northern blot analysis of bovine tissues detected Fscn2 expression only in retina.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE672Hu01 Recombinant Fascin 2 (FSCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE672Hu01 Polyclonal Antibody to Fascin 2 (FSCN2) WB
LAE672Hu71 Biotin-Linked Polyclonal Antibody to Fascin 2 (FSCN2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Fascin 2 (FSCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fascin 2 (FSCN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE672Mu01 Recombinant Fascin 2 (FSCN2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE672Mu02 Recombinant Fascin 2 (FSCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE672Mu01 Polyclonal Antibody to Fascin 2 (FSCN2) WB; IHC; ICC; IP.
PAE672Mu02 Polyclonal Antibody to Fascin 2 (FSCN2) WB; IHC; ICC; IP.
LAE672Mu71 Biotin-Linked Polyclonal Antibody to Fascin 2 (FSCN2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Fascin 2 (FSCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fascin 2 (FSCN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fascin 2 (FSCN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fascin 2 (FSCN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fascin 2 (FSCN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fascin 2 (FSCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fascin 2 (FSCN2) ELISA Kit Customized Service Offer
  1. "Refinement of the RP17 locus for autosomal dominant retinitis pigmentosa, construction of a YAC contig and investigation of the candidate gene retinal fascin."Eur. J. Hum. Genet. 7:332-338(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes."Genomics 65:146-156(2000) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Retinal fascin: functional nature, subcellular distribution, and chromosomal localization."Invest. Ophthalmol. Vis. Sci. 41:2087-2095(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa."Invest. Ophthalmol. Vis. Sci. 42:2395-2400(2001) [PubMed] [Europe PMC] [Abstract]