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SHC-Transforming Protein 1 (SHC1)

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SHC; SHCA; p52SHC; p66; p66SHC; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1

SHC-Transforming Protein 1 (SHC1)
CCC E671
HGNC 10840
MGI 98296
PubMed 19055724
RGD 620446
UniProt P29353
Wiki SHC1
The SHC gene encodes a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains. The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, both containing a C-terminal SH2 domain. Adjacent to the SH2 region is a glycine- and proline-rich region. The 2 proteins differ in their N terminals. SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway. The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways, for example, facilitating the activation of RAS proteins in response to a variety of factors. SHC proteins are rapidly associated with and phosphorylated by growth factor receptors with intrinsic tyrosine kinase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE671Hu01 Recombinant SHC-Transforming Protein 1 (SHC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE671Hu01 Polyclonal Antibody to SHC-Transforming Protein 1 (SHC1) WB; IHC; ICC; IP.
MAE671Hu21 Monoclonal Antibody to SHC-Transforming Protein 1 (SHC1) WB; IHC; ICC; IP.
Assay Kits SEE671Hu ELISA Kit for SHC-Transforming Protein 1 (SHC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SHC-Transforming Protein 1 (SHC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SHC-Transforming Protein 1 (SHC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SHC-Transforming Protein 1 (SHC1) Polyclonal Antibody Customized Service Offer
Assay Kits SEE671Mu ELISA Kit for SHC-Transforming Protein 1 (SHC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SHC-Transforming Protein 1 (SHC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SHC-Transforming Protein 1 (SHC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SHC-Transforming Protein 1 (SHC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SHC-Transforming Protein 1 (SHC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SHC-Transforming Protein 1 (SHC1) ELISA Kit Customized Service Offer
  1. "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction."Cell 70:93-104(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway."EMBO J. 16:706-716(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1."Genomics 42:349-352(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Direct interaction between Shc and the platelet-derived growth factor beta-receptor."J. Biol. Chem. 269:15337-15343(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses."Neuron 12:691-705(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor."J. Biol. Chem. 270:15639-15643(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains."J. Biol. Chem. 270:23258-23262(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain."Mol. Cell. Biol. 15:2500-2508(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation."Blood 88:2833-2840(1996) [PubMed] [Europe PMC] [Abstract]
  14. "The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions."Curr. Biol. 6:1435-1444(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors."J. Biol. Chem. 271:30942-30949(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes."J. Biol. Chem. 272:5915-5920(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src."J. Biol. Chem. 272:13189-13195(1997) [PubMed] [Europe PMC] [Abstract]
  18. "Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation."Mol. Cell. Biol. 17:1824-1831(1997) [PubMed] [Europe PMC] [Abstract]
  19. "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation."Oncogene 15:7-15(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein."J. Biol. Chem. 273:18605-18609(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase."Mol. Cell. Biol. 18:1622-1634(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events."Mol. Cell. Biol. 18:2571-2585(1998) [PubMed] [Europe PMC] [Abstract]
  23. "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells."Blood 93:2707-2720(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Ligand discrimination in signaling through an ErbB4 receptor homodimer."J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]
  25. "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells."J. Biol. Chem. 276:28348-28355(2001) [PubMed] [Europe PMC] [Abstract]
  26. "Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples."Cancer Res. 62:2699-2707(2002) [PubMed] [Europe PMC] [Abstract]
  27. "The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter."J. Biol. Chem. 277:22370-22376(2002) [PubMed] [Europe PMC] [Abstract]
  28. "EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis."J. Cell Biol. 162:661-671(2003) [PubMed] [Europe PMC] [Abstract]
  29. "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma."Cancer Cell 6:347-360(2004) [PubMed] [Europe PMC] [Abstract]
  30. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells."J. Biol. Chem. 279:13224-13233(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress."J. Biol. Chem. 279:27088-27097(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4."J. Biol. Chem. 279:46438-46447(2004) [PubMed] [Europe PMC] [Abstract]
  34. "A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria."J. Biol. Chem. 279:2299-2306(2004) [PubMed] [Europe PMC] [Abstract]
  35. "Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules."J. Biol. Chem. 279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract]
  36. "Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity."J. Cell Biol. 169:331-339(2005) [PubMed] [Europe PMC] [Abstract]
  37. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  38. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  39. "ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation."FEBS Lett. 581:727-734(2007) [PubMed] [Europe PMC] [Abstract]
  40. "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."EMBO J. 27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]
  41. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  42. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  43. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  44. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  46. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  47. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  48. "Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc."J. Virol. 87:11276-11286(2013) [PubMed] [Europe PMC] [Abstract]
  49. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  50. "Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data."J. Mol. Biol. 254:86-95(1995) [PubMed] [Europe PMC] [Abstract]
  51. "Structure and ligand recognition of the phosphotyrosine binding domain of Shc."Nature 378:584-592(1995) [PubMed] [Europe PMC] [Abstract]
  52. "Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor."Proc. Natl. Acad. Sci. U.S.A. 92:7784-7788(1995) [PubMed] [Europe PMC] [Abstract]