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Dihydropyrimidinase Like Protein 2 (DPYSL2)

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CRMP2; DHPRP2; DRP-2; DRP2; ULIP2; Unc-33-like phosphoprotein 2; Collapsin response mediator protein 2

Dihydropyrimidinase Like Protein 2 (DPYSL2)
CCC E666
HGNC 3014
MGI 1349763
PubMed 22954668
RGD 2517
UniProt Q16555
Wiki DPYSL2
The DPYSL2 protein has 572 amino acids. Northern blot analysis detected a 4.9-kb DPYSL2 transcript in all tissues examined except liver.
Expression of the nonphosphorylated form of CRMP2 or inhibition of GSK3-beta induced the formation of multiple axon-like neurites in hippocampal neurons. Expression of constitutively active GSK3-beta impaired neuronal polarization, whereas the nonphosphorylated form of CRMP2 counteracted the inhibitory effects of GSK3-beta, indicating that GSK3-beta regulates neuronal polarity through phosphorylation of CRMP2. Treatment of hippocampal neurons with neurotrophin-3 (NT3) induced inactivation of GSK3-beta and dephosphorylation of CRMP2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Polyclonal Antibody Customized Service Offer
Assay Kits SEE666Mu ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) Polyclonal Antibody Customized Service Offer
Assay Kits SEE666Ra ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33."Nature 376:509-514(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution."Gene 180:157-163(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene."DNA Res. 6:291-297(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (DEC-2008) to UniProtKB
  8. "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522."Biochemistry 39:4267-4275(2000) [PubMed] [Europe PMC] [Abstract]
  9. "CRMP-2 induces axons in cultured hippocampal neurons."Nat. Neurosci. 4:781-782(2001) [PubMed] [Europe PMC] [Abstract]
  10. "GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons."J. Biol. Chem. 279:50176-50180(2004) [PubMed] [Europe PMC] [Abstract]
  11. "CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation."Mol. Cell. Biol. 25:9920-9935(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."EMBO J. 23:9-22(2004) [PubMed] [Europe PMC] [Abstract]
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32."J. Biol. Chem. 284:27393-27401(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2."J. Neurosci. Res. 87:2157-2166(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors."J. Biol. Chem. 285:31918-31922(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "The structure of human collapsin response mediator protein 2, a regulator of axonal growth."J. Neurochem. 101:906-917(2007) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]