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Ubiquitin Conjugating Enzyme E2Z (UBE2Z)

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USE1; HOYS7; Uba6-specific E2 conjugating enzyme 1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z

Ubiquitin Conjugating Enzyme E2Z (UBE2Z)
CCC E664
HGNC 25847
MGI 1343160
UniProt Q9H832
Modification of proteins with ubiquitin (UBB) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007).
Jin et al. (2007) stated that the deduced 354-amino acid UBE2Z protein has a calculated molecular mass of about 38 kD. Database analysis revealed wide expression of the UBE2Z in human tissues and cell lines.
Jin et al. (2007) showed that UBE2Z was specifically charged with ubiquitin by UBA6 (UBE1L2), but not by UBE1.The International Radiation Hybrid Mapping Consortium mapped the UBE2Z gene to chromosome 17 (RH17824).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2Z (UBE2Z) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2Z (UBE2Z) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2Z (UBE2Z) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2Z (UBE2Z) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2Z (UBE2Z) ELISA Kit Customized Service Offer
  1. "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging."Nature 447:1135-1138(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z)."Mol. Biol. Rep. 34:183-188(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel regulators of apoptosis using a high-throughput cell-based screen."Mol. Cells 23:170-174(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]