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Minichromosome Maintenance Deficient 10 (MCM10)

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CNA43; DNA43

Minichromosome Maintenance Deficient 10 (MCM10)
CCC E650
HGNC 18043
MGI 1917274
PubMed 22433841
RGD 1311330
UniProt Q7L590
Wiki MCM10
MCM10 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 10 (MCM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 10 (MCM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 10 (MCM10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 10 (MCM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 10 (MCM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 10 (MCM10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 10 (MCM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 10 (MCM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 10 (MCM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 10 (MCM10) ELISA Kit Customized Service Offer
  1. "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase."Nucleic Acids Res. 28:4769-4777(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cell cycle-dependent proteolysis and phosphorylation of human Mcm10."J. Biol. Chem. 276:48526-48531(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Localization of human Mcm10 is spatially and temporally regulated during the S phase."J. Biol. Chem. 279:32569-32577(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication."Genes Dev. 21:2288-2299(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication."Mol. Biol. Cell 18:4085-4095(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication."EMBO J. 28:3005-3014(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Physical interactions between Mcm10, DNA, and DNA polymerase alpha."J. Biol. Chem. 284:24662-24672(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]