≡

Minichromosome Maintenance Deficient 9 (MCM9)

[Edit]

MCMDC1; C6orf61; DNA helicase MCM9; Minichromosome Maintenance Deficient Domain Containing 1; Mini-chromosome maintenance deficient domain-containing protein 1

Minichromosome Maintenance Deficient 9 (MCM9)
CCC E649
HGNC 21484
MGI 1918817
PubMed 18657502
UniProt Q9NXL9
Minichromosome maintenance proteins, such as MCM9, are required for eukaryotic DNA replication initiation and the early stage of elongation. The deduced 391-amino acid protein shares between 24% and 31% sequence identity with other known MCM proteins, and shows the greatest identity with MCM8. It shares 91% and 90% sequence identity with the mouse and rat orthologs, respectively.
MCM9 contains the MCM2/3/5 family domain of DNA-dependent ATPase motifs. Using Blastn analysis of MCM9, Yoshida (2005) identified in silico mRNA expression of MCM9-associated ESTS in retina, stomach, testis, breast, lymphocyte, and uterus. The deduced 1,141-amino acid protein contains zinc finger-like domains, Walker A and B motifs, and a complete MCM2-7 family domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 9 (MCM9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 9 (MCM9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 9 (MCM9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 9 (MCM9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 9 (MCM9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 9 (MCM9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 9 (MCM9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 9 (MCM9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 9 (MCM9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 9 (MCM9) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family."Gene 362:51-56(2005) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks."Mol. Cell 47:511-522(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Identification, quantification, and evolutionary analysis of a novel isoform of MCM9."Gene 519:41-49(2013) [PubMed] [Europe PMC] [Abstract]
  9. "MCM9 mutations are associated with ovarian failure, short stature, and chromosomal instability."Am. J. Hum. Genet. 95:754-762(2014) [PubMed] [Europe PMC] [Abstract]