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Minichromosome Maintenance Deficient 8 (MCM8)

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REC; C20orf154; DNA helicase MCM8

Minichromosome Maintenance Deficient 8 (MCM8)
CCC E648
HGNC 16147
MGI 1913884
PubMed 15707891
RGD 1305218
UniProt Q9UJA3
Wiki MCM8
MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 8 (MCM8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 8 (MCM8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 8 (MCM8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 8 (MCM8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 8 (MCM8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 8 (MCM8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Deficient 8 (MCM8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Deficient 8 (MCM8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Deficient 8 (MCM8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Deficient 8 (MCM8) ELISA Kit Customized Service Offer
  1. "Identification and functional characterization of a new member of the human Mcm protein family: hMcm8."Nucleic Acids Res. 31:570-579(2003) [PubMed] [Europe PMC] [Abstract]
  2. "A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13."Nucleic Acids Res. 31:2915-2925(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin."Mol. Cell. Biol. 25:1560-1568(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F."Gene 367:126-134(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication."Microsc. Res. Tech. 71:288-297(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks."Mol. Cell 47:511-522(2012) [PubMed] [Europe PMC] [Abstract]