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Receptor Interacting Serine Threonine Kinase 1 (RIPK1)

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RIP; Receptor-Interacting Protein; Cell death protein RIP; Serine/threonine-protein kinase RIP

Receptor Interacting Serine Threonine Kinase 1 (RIPK1)
CCC E640
HGNC 10019
MGI 108212
PubMed 22814620
RGD 1310158
UniProt Q13546
Wiki RIPK1
Two cell surface cytokine receptors, FAS and tumor necrosis factor (TNF) receptor, trigger apoptosis by natural ligands or specific agonist antibodies. Both receptors contain a conserved intracellular death domain. Using a yeast 2-hybrid screen with the cytoplasmic domain of FAS as bait, Stanger et al. (1995) isolated partial cDNAs encoding a receptor-interacting protein which they designated RIP. They used the partial cDNAs to isolate mouse cDNAs corresponding to the entire Rip coding region. Hsu et al. (1996) isolated a full-length human RIP cDNA. They reported that the predicted 671-amino acid RIP protein contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region that they called the intermediate domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE640Hu01 Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE640Hu21 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
PAE640Hu01 Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
MAE640Hu22 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC
MAE640Hu23 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
Assay Kits SEE640Hu ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEE640Hu High Sensitive ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Polyclonal Antibody Customized Service Offer
Assay Kits SEE640Mu ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE640Ra01 Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE640Ra21 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
PAE640Ra01 Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
Assay Kits SEE640Ra ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex."Immunity 4:387-396(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."Cell 81:513-523(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis."Genes Dev. 13:2514-2526(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."EMBO J. 18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]
  8. "RIP3, a novel apoptosis-inducing kinase."J. Biol. Chem. 274:16871-16875(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation."Mol. Cell. Biol. 19:5759-5767(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis."Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule."Nat. Immunol. 1:489-495(2000) [PubMed] [Europe PMC] [Abstract]
  12. "The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome."J. Biol. Chem. 276:8865-8874(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation."J. Biol. Chem. 277:15985-15991(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."J. Biol. Chem. 277:9505-9511(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  16. "ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation."J. Biol. Chem. 279:16847-16853(2004) [PubMed] [Europe PMC] [Abstract]
  17. "De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling."Nature 430:694-699(2004) [PubMed] [Europe PMC] [Abstract]
  18. "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction."Nat. Immunol. 6:981-988(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO."Mol. Cell 22:245-257(2006) [PubMed] [Europe PMC] [Abstract]
  20. "RIP1, a kinase on the crossroads of a cell's decision to live or die."Cell Death Differ. 14:400-410(2007) [PubMed] [Europe PMC] [Abstract]
  21. "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."J. Biol. Chem. 282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]
  22. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
  23. "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation."Curr. Biol. 18:641-649(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of RIP1 kinase as a specific cellular target of necrostatins."Nat. Chem. Biol. 4:313-321(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1."J. Biol. Chem. 283:16966-16970(2008) [PubMed] [Europe PMC] [Abstract]
  26. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."Cell 137:1112-1123(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."Cell 137:1100-1111(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Response: CARP1 regulates induction of NF-kappaB by TNFalpha."Curr. Biol. 19:R17-R19(2009)
  30. "The role of the kinases RIP1 and RIP3 in TNF-induced necrosis."Sci. Signal. 3:RE4-RE4(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Linear ubiquitination prevents inflammation and regulates immune signalling."Nature 471:591-596(2011) [PubMed] [Europe PMC] [Abstract]
  33. "cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]
  34. "The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."Cell 148:228-243(2012) [PubMed] [Europe PMC] [Abstract]
  35. "Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]
  36. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  37. "Structural basis of RIP1 inhibition by necrostatins."Structure 21:493-499(2013) [PubMed] [Europe PMC] [Abstract]
  38. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]