Guanylate Binding Protein 1, Interferon Inducible (GBP1)

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GTP-binding protein 1; Guanine nucleotide-binding protein 1

Guanylate Binding Protein 1, Interferon Inducible (GBP1)
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP1, GBP2, and GBP5 contain a C-terminal CaaX isoprenylation motif. EST database analysis showed wide expression of GBP1 in human tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Hu01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE637Hu01 Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) WB; IHC; ICC; IP.
Assay Kits SEE637Hu ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Mu01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Po01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE637Po01 Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer
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  11. "A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication."FASEB J. 26:1290-1300(2012) [PubMed] [Europe PMC] [Abstract]
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  13. "Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism."EMBO J. 19:4555-4564(2000) [PubMed] [Europe PMC] [Abstract]
  14. "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP."Nature 440:101-104(2006) [PubMed] [Europe PMC] [Abstract]