Guanylate Binding Protein 5 (GBP5)

[Edit]

GBP-TA antigen GTP-binding protein 5; Guanine nucleotide-binding protein 5

Guanylate Binding Protein 5 (GBP5)
Like all GBPs, GBP5 has a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. Like GBP1 and GBP2, GBP5 has a C-terminal CaaX isoprenylation motif. EST database analysis indicated wide expression of GBP5 in human tissues. Immunofluorescence analysis demonstrated cytoplasmic expression of GBP5. Irrespective of stimulation, GBP5 was constitutively expressed in the Golgi apparatus.The GBP5ta splice variant lacks exons 11 and 12 leading to C-terminal deletion of 97 amino acids and loss of a putative isoprenylation site. The GBP5a variant lacks the noncoding exon 2.The deduced 586-amino acid protein has a predicted molecular mass of 67 kD and contains a guanylate-binding site composed of 3 motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE634Hu01 Recombinant Guanylate Binding Protein 5 (GBP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE634Hu01 Polyclonal Antibody to Guanylate Binding Protein 5 (GBP5) WB; IHC; ICC; IP.
Assay Kits SEE634Hu ELISA Kit for Guanylate Binding Protein 5 (GBP5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Binding Protein 5 (GBP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Binding Protein 5 (GBP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Binding Protein 5 (GBP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 5 (GBP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 5 (GBP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE634Ra01 Recombinant Guanylate Binding Protein 5 (GBP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE634Ra01 Polyclonal Antibody to Guanylate Binding Protein 5 (GBP5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 5 (GBP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 5 (GBP5) ELISA Kit Customized Service Offer
  1. "GBP-5 splicing variants: New guanylate-binding proteins with tumor-associated expression and antigenicity."J. Invest. Dermatol. 122:1510-1517(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Unique features of different members of the human guanylate-binding protein family."J. Interferon Cytokine Res. 27:44-52(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner."PLoS ONE 5:E14246-E14246(2010) [PubMed] [Europe PMC] [Abstract]
  7. "GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals."Science 336:481-485(2012) [PubMed] [Europe PMC] [Abstract]