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Ubiquitin Conjugating Enzyme E2N (UBE2N)

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UBC13; UbcH-ben; BLU; Ubiquitin carrier protein N; Ubiquitin-protein ligase N; Bendless-like ubiquitin-conjugating enzyme

Ubiquitin Conjugating Enzyme E2N (UBE2N)
CCC E609
HGNC 12492
MGI 1934835
PubMed 24556694
RGD 621096
UniProt P61088
Wiki UBE2N
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
The UBE2N gene, which the authors referred to as UBCHBEN, encodes a protein of 152 amino acids with a calculated molecular mass of 17.1 kD. The amino acid sequence shows 80% identity with the Drosophila 'bendless' gene product (ubiquitin-conjugating enzyme E2). Northern blot analysis detected a major 1.4- and a minor 2.4-kb transcript in all tissues examined, with the highest expression in heart, skeletal muscle, and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2N (UBE2N) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2N (UBE2N) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2N (UBE2N) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2N (UBE2N) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2N (UBE2N) ELISA Kit Customized Service Offer
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  3. , Submitted (DEC-2008) to UniProtKB
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  19. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1."Nature 466:941-946(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  24. "Covalent protein modification with ISG15 via a conserved cysteine in the hinge region."PLoS ONE 7:E38294-E38294(2012) [PubMed] [Europe PMC] [Abstract]
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  27. "Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation."J. Biol. Chem. 287:23900-23910(2012) [PubMed] [Europe PMC] [Abstract]
  28. "OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function."Mol. Cell 45:384-397(2012) [PubMed] [Europe PMC] [Abstract]
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