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Ubiquitin Conjugating Enzyme E2M (UBE2M)

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UBC-RS2; UBC12; hUbc12; NEDD8 carrier protein; NEDD8 protein ligase; NEDD8-conjugating enzyme Ubc12

Ubiquitin Conjugating Enzyme E2M (UBE2M)
CCC E608
HGNC 12491
MGI 108278
PubMed 21477582
RGD 1307614
UniProt P61081
Wiki UBE2M
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
UBE2M encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.By searching sequence databases, the authors identified a cDNA encoding the human homolog of this 22-kD protein. The predicted 183-amino acid human protein shares 42% sequence identity with S. cerevisiae Ubc12, a member of the E2 enzyme family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2M (UBE2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2M (UBE2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2M (UBE2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2M (UBE2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2M (UBE2M) ELISA Kit Customized Service Offer
  1. "A new NEDD8-ligating system for cullin-4A."Genes Dev. 12:2263-2268(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway."J. Biol. Chem. 274:12036-12042(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo."J. Biol. Chem. 275:17008-17015(2000) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification."Mol. Cell 33:483-495(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8."Nat. Struct. Mol. Biol. 11:927-935(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1."Mol. Cell 17:341-350(2005) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex."Science 334:674-678(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes."Structure 21:42-53(2013) [PubMed] [Europe PMC] [Abstract]