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Ubiquitin Conjugating Enzyme E2D3 (UBE2D3)

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UBC4/5; E2(17)KB3; UBCH5C; Ubiquitin carrier protein D3; Ubiquitin-protein ligase D3

Ubiquitin Conjugating Enzyme E2D3 (UBE2D3)
CCC E604
HGNC 12476
MGI 1913355
PubMed 17420285
RGD 619912
UniProt P61077
Wiki UBE2D3
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
Ubiquitin-conjugating enzyme E2 D3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D3 (UBE2D3) ELISA Kit Customized Service Offer
  1. "Identification of a family of closely related human ubiquitin conjugating enzymes."J. Biol. Chem. 270:30408-30414(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha."J. Biol. Chem. 274:14823-14830(1999) [PubMed] [Europe PMC] [Abstract]
  6. "CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein."EMBO Rep. 2:1133-1138(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase."Biochem. Biophys. Res. Commun. 302:869-872(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53."J. Biol. Chem. 279:36440-36444(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo."J. Biol. Chem. 279:42169-42181(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The poxvirus p28 virulence factor is an E3 ubiquitin ligase."J. Biol. Chem. 279:54110-54116(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites."EMBO J. 25:2178-2188(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Physical and functional interactions between ZIP kinase and UbcH5."Biochem. Biophys. Res. Commun. 372:708-712(2008) [PubMed] [Europe PMC] [Abstract]
  13. "PCNA is ubiquitinated by RNF8."Cell Cycle 7:3399-3404(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation."Mol. Biol. Cell 19:3454-3462(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation."Mol. Cell 32:21-31(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions."Mol. Microbiol. 67:1307-1319(2008) [PubMed] [Europe PMC] [Abstract]
  17. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  18. "The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme."J. Biol. Chem. 285:23687-23698(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate."Mol. Cell 37:784-796(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids."Nature 474:105-108(2011) [PubMed] [Europe PMC] [Abstract]
  22. "A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination."Mol. Cell 21:873-880(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of UBCH5C."Submitted (FEB-2009) to the PDB data bank
  24. "Crystal structure of the U-Box domain of human e4b ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme."Submitted (MAY-2010) to the PDB data bank