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Ubiquitin Conjugating Enzyme E2D2 (UBE2D2)

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UBC4/5; E2(17)KB2; PUBC1; UBC4; UBCH5B; Ubiquitin carrier protein D2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1

Ubiquitin Conjugating Enzyme E2D2 (UBE2D2)
CCC E603
HGNC 12475
MGI 1930715
PubMed 20585566
UniProt P62837
Wiki UBE2D2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
Ubiquitin-conjugating enzyme E2 D2 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. UBE2D2 has been shown to interact with PJA1, Baculoviral IAP repeat-containing protein 3, PJA2, UBE3A and NEDD4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D2 (UBE2D2) ELISA Kit Customized Service Offer
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  7. , Submitted (MAR-2007) to UniProtKB
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  9. "SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4."Oncogene 19:3529-3536(2000) [PubMed] [Europe PMC] [Abstract]
  10. "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."Genomics 79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
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  13. "Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology."Biochem. J. 409:723-729(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation."Biol. Reprod. 79:914-920(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor."J. Biol. Chem. 283:14190-14197(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3."Mol. Cell 36:315-325(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity."Cell 141:315-330(2010) [PubMed] [Europe PMC] [Abstract]
  18. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme."J. Biol. Chem. 285:23687-23698(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the ubiquitin-conjugating enzyme UbcH5B."J. Mol. Biol. 344:513-526(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates."Structure 18:138-147(2010) [PubMed] [Europe PMC] [Abstract]