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Ubiquitin Conjugating Enzyme E2D1 (UBE2D1)

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E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A; Stimulator Of Fe Transport; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2-17 kDa 1

Ubiquitin Conjugating Enzyme E2D1 (UBE2D1)
CCC E595
HGNC 12474
MGI 2384911
PubMed 22438555
RGD 1307886
UniProt P51668
Wiki UBE2D1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
UBE2D1 encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE595Hu01 Recombinant Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2D1 (UBE2D1) ELISA Kit Customized Service Offer
  1. "Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53."Proc. Natl. Acad. Sci. U.S.A. 91:8797-8801(1994) [PubMed] [Europe PMC] [Abstract]
  2. "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis."Blood 101:3288-3293(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Functional expression cloning and characterization of SFT, a stimulator of Fe transport."J. Cell Biol. 139:895-905(1997) [PubMed] [Europe PMC] [Abstract]
  7. ErratumJ. Cell Biol. 147:205-205(1999)
  8. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase."Br. J. Cancer 89:1538-1544(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology."Biochem. J. 409:723-729(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide."Exp. Cell Res. 314:3605-3613(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor."J. Biol. Chem. 283:14190-14197(2008) [PubMed] [Europe PMC] [Abstract]
  13. "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."Arch. Biochem. Biophys. 483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3."Mol. Cell 36:315-325(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  16. "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor."Genes Dev. 25:1262-1274(2011) [PubMed] [Europe PMC] [Abstract]