B-Cell CLL/Lymphoma 8 (Bcl8)

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BCL8A; NBEAP1; Neurobeachin pseudogene 1

B-Cell CLL/Lymphoma 8 (Bcl8)
A probe derived from the BCL8 locus detected a transcript in human testis and prostate, whereas no expression was found in spleen, thymus, or blood leukocytes. Analysis of the BCL8 cDNA clones isolated from human testis cDNA library showed that the BCL8 gene generates a major transcript of 2.6 kb and a less prominent 4.5-kb species due to differential polyadenylation. BCL8 expression was detected in all patients carrying 15q11-q13 abnormalities and in a fraction of randomly selected DLCL patients. These results suggested that the BCL8 gene is not normally expressed in lymphoid tissues, but its expression can be activated by chromosomal translocation or by other mechanisms in DLCL. Ectopic expression of BCL8 in a significant proportion of DLCL suggests an important role for this gene in the molecular pathogenesis of B-cell lymphoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 8 (Bcl8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 8 (Bcl8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 8 (Bcl8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 8 (Bcl8) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 8 (Bcl8) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma."Proc. Natl. Acad. Sci. U.S.A. 94:5728-5732(1997) [PubMed] [Europe PMC] [Abstract]
  4. "BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function."Genomics 80:158-165(2002) [PubMed] [Europe PMC] [Abstract]