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T-Cell Leukemia/Lymphoma Protein 1B (TCL1B)

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TML1; Syncytiotrophoblast-specific protein; TCL1/MTCP1-like protein 1

T-Cell Leukemia/Lymphoma Protein 1B (TCL1B)
CCC E567
HGNC 11649
PubMed 24042734
UniProt O95988
Wiki TCL1B
TCL1B, a novel member of the TCL1 gene family. The approximately 1.2-kb TCL1B cDNA encodes a 14-kD protein that contains 128 amino acids and shows 60% sequence similarity to the TCL1A protein. By PCR analysis of a radiation hybrid panel, they mapped the TCL1B gene to chromosome 14q32.1. Pulse-field analysis of a positive BAC clone revealed that the TCL1B gene is located approximately 16 kb centromeric of the TCL1A gene.
Expression profiles of the 2 genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T-cell leukemia by rearrangement of the 14q32.1 region. Thus, translocations and inversions at 14q32.1 in T-cell malignancies involve 2 oncogenes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Leukemia/Lymphoma Protein 1B (TCL1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1B (TCL1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1B (TCL1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1B (TCL1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1B (TCL1B) ELISA Kit Customized Service Offer
  1. "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus."Cancer Res. 59:2313-2317(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes."Proc. Natl. Acad. Sci. U.S.A. 96:2949-2951(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The protooncogene TCL1 is an Akt kinase coactivator."Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]