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Cell Adhesion Molecule 3 (CADM3)

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BIgR; TSLL1; NECL1; SynCAM3; Necl-1; IGSF4B; Nectin-Like 1; Immunoglobulin Superfamily,Member 4B; Brain immunoglobulin receptor; TSLC1-like protein 1

Cell Adhesion Molecule 3 (CADM3)
CCC E543
HGNC 17601
MGI 2137858
PubMed 23505055
RGD 1307035
UniProt Q8N126
Wiki CADM3
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins.The predicted 398-amino acid TSLL1 protein has an extracellular domain, a transmembrane domain, and a short cytoplasmic domain. The extracellular domain contains 3 Ig-like, C2-type loops with several potential N-glycosylation sites. NECL1 showed calcium-independent homophilic cell-cell adhesion activity. Furthermore, it showed calcium-independent heterophilic cell-cell adhesion activity with NECL2 (IGSF4), nectin-1 (PVRL1), or nectin-3 (PVRL3), but not with NECL5 (PVR) or nectin-2 (PVRL2). Yeast 2-hybrid analysis indicated that the PDZ domain-binding motif of NECL1 bound to the L27 domain-containing proteins DLG3, PALS2 (MPP6), and CASK, but unlike most other nectins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule 3 (CADM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule 3 (CADM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule 3 (CADM3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule 3 (CADM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule 3 (CADM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule 3 (CADM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule 3 (CADM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule 3 (CADM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule 3 (CADM3) ELISA Kit Customized Service Offer
  1. "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins."Oncogene 20:5401-5407(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity."Biochim. Biophys. Acta 1778:1429-1435(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule."J. Biol. Chem. 281:10610-10617(2006) [PubMed] [Europe PMC] [Abstract]