Cell Adhesion Molecule 2 (CADM2)

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NECL3; Necl-3; SynCAM2; IGSF4D; Nectin-Like 3; Immunoglobulin Superfamily Member 4D; Nectin-like protein 3

Cell Adhesion Molecule 2 (CADM2)
By searching databases for sequences similar to SYNCAM (IGSF4), Biederer (2006) identified IGSF4D, which he called SYNCAM2. SYNCAM2 contains an N-terminal signal peptide, followed by 3 Ig-like domains of the V-set, C1-set, and I-set subclasses, a transmembrane segment, and an intracellular C terminus with motifs for interaction with protein 4.1 (EPB41) and type II PDZ domains. The third Ig-like domain contains N-glycosylation sites, and alternative splicing introduces potential O-glycosylation sites prior to the transmembrane region. SYNCAM2 shares highest homology with other SYNCAM proteins in the Ig-like domains and the cytosolic protein-protein interaction motifs.the IGSF4D gene contains 10 exons and spans 1.11 Mb. It has 2 alternative first exons, and the first intron is 843 kb long.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE542Hu01 Recombinant Cell Adhesion Molecule 2 (CADM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule 2 (CADM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule 2 (CADM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule 2 (CADM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Polyclonal Antibody Customized Service Offer
Assay Kits SEE542Mu ELISA Kit for Cell Adhesion Molecule 2 (CADM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule 2 (CADM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule 2 (CADM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule 2 (CADM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule 2 (CADM2) ELISA Kit Customized Service Offer
  1. "A novel splicing variant of CADM2 as a protective transcript of psoriasis."Biochem. Biophys. Res. Commun. 412:626-632(2011) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion."BMC Neurosci. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]