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Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1)

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SLC25A12; ARALAR1; Solute Carrier Family 25 Member 12,Mitochondrial Carrier,Aralar; Calcium-binding mitochondrial carrier protein Aralar1

Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1)
CCC E462
HGNC 10982
MGI 1926080
PubMed 19360665
UniProt O75746
Wiki SLC25A12
The SLC25A12 gene encodes aralar, a protein that functions in the transport of aspartate from mitochondria to cytosol in exchange for glutamate. Aralar also plays a role in the transfer of cytosolic reducing equivalents into mitochondria as a member of the malate-aspartate NADH shuttle.
The N-terminal portion of the predicted 678-amino acid aralar protein contains 3 canonical EF-hand calcium-binding domains and 2 imperfect EF-hand domains. The authors demonstrated that this half of the protein bound calcium in vitro. The C-terminal half of aralar shares 28 to 29% identity with proteins of the mitochondrial solute carrier family, including oxoglutarate/malate carrier, ADP/ATP translocase-2, UCP1, and tricarboxylate carrier.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE462Hu01 Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain."J. Biol. Chem. 273:23327-23334(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria."EMBO J. 20:5060-5069(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein."Nat. Genet. 22:159-163(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "AGC1 deficiency associated with global cerebral hypomyelination."N. Engl. J. Med. 361:489-495(2009) [PubMed] [Europe PMC] [Abstract]
  10. ErratumN. Engl. J. Med. 361:731-731(2009)
  11. "AGC1 deficiency causes infantile epilepsy, abnormal myelination, and reduced n-acetylaspartate." JIMD Rep. 14:77-85(2014) [PubMed] [Europe PMC] [Abstract]