≡

Organic Cation Transporter 2 (OCT2)

[Edit]

SLC22A2; Solute Carrier Family 22 Member 2

Organic Cation Transporter 2 (OCT2)
CCC E442
HGNC 10966
MGI 1335072
PubMed 24002095
RGD 61936
UniProt O15244
Wiki SLC22A2
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. SLC22A2 contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 2 (OCT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 2 (OCT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 2 (OCT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 2 (OCT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 2 (OCT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 2 (OCT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 2 (OCT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 2 (OCT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 2 (OCT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 2 (OCT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 2 (OCT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 2 (OCT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 2 (OCT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 2 (OCT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 2 (OCT2) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of two human polyspecific organic cation transporters."DNA Cell Biol. 16:871-881(1997) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney."J. Am. Soc. Nephrol. 13:1703-1710(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2."Hum. Genet. 106:627-635(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine."Mol. Pharmacol. 54:342-352(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules."Pharm. Res. 18:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)."J. Pharmacol. Exp. Ther. 304:810-817(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)."Eur. J. Pharmacol. 503:25-30(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2."Am. J. Pathol. 167:1477-1484(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters."J. Pharmacol. Exp. Ther. 315:337-345(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Metformin transport by renal basolateral organic cation transporter hOCT2."Pharm. Res. 22:255-259(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of regulatory mechanisms and states of human organic cation transporter 2."Am. J. Physiol. 290:C1521-C1531(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Organic cation transporters are determinants of oxaliplatin cytotoxicity."Cancer Res. 66:8847-8857(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2."Drug Metab. Pharmacokinet. 21:432-436(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)."J. Pharmacol. Exp. Ther. 319:879-886(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."Biochem. Pharmacol. 74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
  21. "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua."Mol. Reprod. Dev. 74:1303-1311(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function."Pharmacogenetics 12:395-405(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin."J. Hum. Genet. 52:117-122(2007) [PubMed] [Europe PMC] [Abstract]