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Natural Resistance Associated Macrophage Protein 1 (NRAMP1)

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SLC11A1; LSH; NRAMP; Solute Carrier Family 11 Member 1,Proton-Coupled Divalent Metal Ion Transporters

Natural Resistance Associated Macrophage Protein 1 (NRAMP1)
CCC E425
HGNC 10907
MGI 1345275
PubMed 22706314
RGD 1601463
UniProt P49279
Wiki SLC11A1
SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens.
Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.Macrophages; peripheral blood leukocytes, lungs, spleen and liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Natural Resistance Associated Macrophage Protein 1 (NRAMP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natural Resistance Associated Macrophage Protein 1 (NRAMP1) ELISA Kit Customized Service Offer
  1. "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression."J. Exp. Med. 180:1741-1752(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes."Immunol. Lett. 47:93-96(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35."Mamm. Genome 11:755-762(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of human Nramp cDNA."Biochem. Biophys. Res. Commun. 204:1074-1080(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism."Mol. Med. 1:194-205(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene."Am. J. Hum. Genet. 56:845-853(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease."Proc. Natl. Acad. Sci. U.S.A. 102:12183-12188(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism."Genes Immun. 7:185-189(2006) [PubMed] [Europe PMC] [Abstract]