Na+ Taurocholate Cotransporting Polypeptide (NTCP)

[Edit]

SLC10A1; NTCP1; Solute Carrier Family 10 Member 1,Sodium/Bile Acid Cotransporter Family; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter

Na+ Taurocholate Cotransporting Polypeptide (NTCP)
Sodium/bile acid cotransporters are integral membrane glycoproteins. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2;), and the other being found in the basolateral membranes of hepatocytes (SLC10A1). SLC10A1 contains an exoplasmic N terminus, an odd number of transmembrane regions, and a cytoplasmic C terminus. Alanine insertion experiments confirmed that 7 of the 9 hydrophobic stretches are membrane-integrated, with secondary structures and transport activity sensitive to positional displacement. Two amphipathic sequences are critical for intramolecular interactions and for proper trafficking of SLC10A1 to the plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE421Hu01 Recombinant Na+ Taurocholate Cotransporting Polypeptide (NTCP) Positive Control; Immunogen; SDS-PAGE; WB.
RPE421Hu02 Recombinant Na+ Taurocholate Cotransporting Polypeptide (NTCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE421Hu21 Monoclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) WB; IHC; ICC; IP.
PAE421Hu01 Polyclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) WB; IHC; ICC; IP.
Assay Kits SEE421Hu ELISA Kit for Na+ Taurocholate Cotransporting Polypeptide (NTCP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Na+ Taurocholate Cotransporting Polypeptide (NTCP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Na+ Taurocholate Cotransporting Polypeptide (NTCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Na+ Taurocholate Cotransporting Polypeptide (NTCP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Na+ Taurocholate Cotransporting Polypeptide (NTCP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Na+ Taurocholate Cotransporting Polypeptide (NTCP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Na+ Taurocholate Cotransporting Polypeptide (NTCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Na+ Taurocholate Cotransporting Polypeptide (NTCP) ELISA Kit Customized Service Offer
  1. "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter."J. Clin. Invest. 93:1326-1331(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]