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Solute Carrier Family 7, Member 9 (SLC7A9)

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CSNU3; Cationic Amino Acid Transporter,y+ System; b(0,+)-type amino acid transporter 1; Glycoprotein-associated amino acid transporter b0,+AT1

Solute Carrier Family 7, Member 9 (SLC7A9)
CCC E419
HGNC 11067
MGI 1353656
PubMed 12371955
RGD 619905
UniProt P82251
Wiki SLC7A9
The SLC7A9 cDNA is polyadenylated and contains an open reading frame encoding a 487-amino acid protein. The protein, designated b(0,+)AT for b(0,+) amino acid transporter, belongs to a family of light subunits of amino acid transporters expressed in kidney, liver, small intestine, and placenta. Northern blot analysis revealed that the SLC7A9 gene was expressed as an approximately 1.9-kb transcript in these tissues. The tissue distribution of b(0,+)AT was consistent with that of a renal basic amino acid transporter (see SLC3A1, or rBAT) light subunit. As expected, b(0,+)AT brought rBAT to the plasma membrane in cotransfected COS cells. In contrast, transfection of rBAT alone resulted in the blockage of the expressed protein in the endoplasmic reticulum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE419Hu01 Recombinant Solute Carrier Family 7, Member 9 (SLC7A9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE419Hu01 Polyclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) WB; IHC; ICC; IP.
MAE419Hu21 Monoclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) WB; IHC; ICC; IP.
Assay Kits SEE419Hu ELISA Kit for Solute Carrier Family 7, Member 9 (SLC7A9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 7, Member 9 (SLC7A9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 7, Member 9 (SLC7A9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 7, Member 9 (SLC7A9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 7, Member 9 (SLC7A9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 7, Member 9 (SLC7A9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 7, Member 9 (SLC7A9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 7, Member 9 (SLC7A9) ELISA Kit Customized Service Offer
  1. "Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (b0,+AT) of rBAT." Nat. Genet. 23:52-57(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Luminal heterodimeric amino acid transporter defective in cystinuria."Mol. Biol. Cell 10:4135-4147(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human cystinuria-related transporter: localization and functional characterization."Kidney Int. 59:1821-1833(2001) [PubMed] [Europe PMC] [Abstract]
  4. "SLC7A9 mutations in all three cystinuria subtypes."Kidney Int. 62:1550-1559(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney."Am. J. Physiol. 283:F540-F548(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-type I cystinuria." Hum. Mol. Genet. 10:305-316(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Cystinuria in children: distribution and frequencies of mutations in the SLC3A1 and SLC7A9 genes."Kidney Int. 62:1136-1142(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Mutation analysis of SLC7A9 in cystinuria patients in Sweden."Genet. Test. 7:13-20(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular genetic analysis of SLC3A1 and SLC7A9 genes in Czech and Slovak cystinuric patients."Ann. Hum. Genet. 69:501-507(2005) [PubMed] [Europe PMC] [Abstract]
  12. "New insights into cystinuria: 40 new mutations, genotype-phenotype correlation, and digenic inheritance causing partial phenotype."J. Med. Genet. 42:58-68(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter."Kidney Int. 69:1198-1206(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Twenty-four novel mutations identified in a cohort of 85 patients by direct sequencing of the SLC3A1 and SLC7A9 cystinuria genes."Genet. Test. 12:351-355(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large rearrangements detected by MLPA, point mutations, and survey of the frequency of mutations within the SLC3A1 and SLC7A9 genes in a cohort of 172 cystinuric Italian patients."Mol. Genet. Metab. 99:42-52(2010) [PubMed] [Europe PMC] [Abstract]