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Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A)

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MYPT1; MBS; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit

Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A)
CCC E409
HGNC 7618
MGI 1309528
PubMed 22516431
RGD 620013
UniProt O14974
Wiki Ppp1r12A
The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase, which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 12A (PPP1R12A) ELISA Kit Customized Service Offer
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