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Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A)

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CPI-17; PPP1INL; 17-kDa PKC-Potentiated Inhibitory Protein Of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa

Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A)
CCC E407
HGNC 14871
MGI 1931139
PubMed 17301291
RGD 620536
UniProt Q96A00
Wiki PPP1R14A
PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Human and pig PPP1R14A share 93% sequence similarity, including a conserved PKC phosphorylation motif containing a threonine that is phosphorylated in pig. PPP1R14A shares about 87% similarity with mouse and rat Ppp1r14a, but the murine proteins have calculated pIs that are significantly less basic than that of human PPP1R14A, which is 10.21. a 0.6-kb transcript in all human tissues examined, with highest levels in heart, prostate, testis, ovary, colon, small intestine, and pancreas. The tissue distributions of human and porcine PPP1R14A were similar, but they differed from those of rat and mouse Ppp1r14a, which were more specific. Murine Ppp1r14a expression was high in lung, moderate in testis and brain, and low in heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 14A (PPP1R14A) ELISA Kit Customized Service Offer
  1. "Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase."Biochem. Biophys. Res. Commun. 285:1040-1045(2001) [PubMed] [Europe PMC] [Abstract]
  2. "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Association of CPI-17 with protein kinase C and casein kinase I."Biochem. Biophys. Res. Commun. 316:39-47(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]