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Sodium Dependent Phosphate Transport Protein 1 (NPT1)

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SLC17A1; NAPI-1; Solute Carrier Family 17 Member 1,Sodium Phosphate; Renal Na(+)-dependent phosphate cotransporter 1; Sodium/phosphate cotransporter 1

Sodium Dependent Phosphate Transport Protein 1 (NPT1)
CCC E378
HGNC 10929
MGI 103209
PubMed 22541845
UniProt Q14916
Wiki SLC17A1
The sodium-phosphate cotransport system, located in the proximal convoluted renal tubule, is essential to phosphate homeostasis in animals and humans. By low stringency screening of a human kidney cortex cDNA library with a rabbit NaPi1 cDNA, Chong et al. (1993) isolated a cDNA encoding a human sodium-dependent phosphate transport protein. By Southern hybridization to HindIII-digested DNA from a monochromosomal human-rodent somatic cell hybrid panel, Chong et al. (1993) mapped the human NPT1 gene to chromosome 6. Localization to 6p23-p21.3 was found by Southern hybridization to HindIII-digested DNA from a human chromosome 6 somatic cell hybrid deletion panel. SLC17A1 locus as the third associated with gout at a genome-wide level of significance.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Dependent Phosphate Transport Protein 1 (NPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Dependent Phosphate Transport Protein 1 (NPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Dependent Phosphate Transport Protein 1 (NPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Dependent Phosphate Transport Protein 1 (NPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Dependent Phosphate Transport Protein 1 (NPT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Dependent Phosphate Transport Protein 1 (NPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Dependent Phosphate Transport Protein 1 (NPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Dependent Phosphate Transport Protein 1 (NPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Dependent Phosphate Transport Protein 1 (NPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Dependent Phosphate Transport Protein 1 (NPT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23."Genomics 18:355-359(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene."Biochim. Biophys. Acta 1396:267-272(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression."Biochem. J. 305:81-85(1995) [PubMed] [Europe PMC] [Abstract]