Urea Transporter, Erythrocyte (UTE)
[Edit]SLC14A1; HUT11; HsT1341; JK; RACH1; UT-B1; UT1; Solute Carrier Family 14 Member 1,Urea Transporter,Kidd Blood Group
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The possibility that the urea transporter of human erythrocytes may be related to Kidd blood group antigens was raised by the observation that red cells from Jk(a-b-) individuals which lack Kidd antigens exhibited an increased resistance to lysis in aqueous 2 M urea. These cells exhibited a defect in urea transport, whereas chloride, water, and ethylene glycol permeabilities, as well as aquaporin-associated Colton blood group antigens, were the same as in control cells. Olives et al. (1995) demonstrated that, indeed, the urea transporter of human erythrocytes is encoded by the Kidd locus. In coupled transcription-translation assays, the UTE cDNA directed the synthesis of a 36-kD protein that was immunoprecipitated by human anti-Jk(3) antibody produced by immunized Jk(a-b-) donors whose red cells lack Kidd antigens.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Urea Transporter, Erythrocyte (UTE) | Recombinant Protein Customized Service Offer |
| Antibodies | PAE377Mu01 | Polyclonal Antibody to Urea Transporter, Erythrocyte (UTE) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Urea Transporter, Erythrocyte (UTE) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Urea Transporter, Erythrocyte (UTE) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Urea Transporter, Erythrocyte (UTE) | Recombinant Protein Customized Service Offer |
| Antibodies | PAE377Ra01 | Polyclonal Antibody to Urea Transporter, Erythrocyte (UTE) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Urea Transporter, Erythrocyte (UTE) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Urea Transporter, Erythrocyte (UTE) | ELISA Kit Customized Service Offer |
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- "At physiological expression levels, the Kidd blood group/urea transporter protein is not a water channel."J. Biol. Chem. 274:30228-30235(1999) [PubMed] [Europe PMC] [Abstract]
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Erythroid urea transporter deficiency due to novel JKnull alleles."Transfusion 48:365-372(2008) [PubMed] [Europe PMC] [Abstract]
- "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
- "Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns."Blood 96:1566-1573(2000) [PubMed] [Europe PMC] [Abstract]
- "Genomic characterization of the Kidd blood group gene: different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns."Transfusion 40:69-74(2000) [PubMed] [Europe PMC] [Abstract]
- "Two novel Jk(null) alleles derived from 222C>A in Exon 5 and 896G>A in Exon 9 of the JK gene."Transfusion 49:259-264(2009) [PubMed] [Europe PMC] [Abstract]