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Fer Tyrosine Kinase (FER)

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TYK3; Tyrosine kinase 3; Proto-oncogene c-Fer; Phosphoprotein NCP94; Fps/Fes Related Tyrosine Kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer

Fer Tyrosine Kinase (FER)
CCC E370
HGNC 3655
MGI 105917
PubMed 21518868
UniProt P16591
Wiki FER
Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.cell-permeable (Trojan) peptides containing the third helix of the antennapedia homeodomain fused to a peptide mimicking the juxtamembrane (JMP) region of the cytoplasmic domain of N-cadherin (CDH2) result in the inhibition of both CDH2 and beta-1 integrin (ITGB1) function. Microscopic analysis showed that expression of JMP, which binds to the cytoplasmic domain of CDH2, results in a reduction of neurite outgrowth on cadherin substrates. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fer Tyrosine Kinase (FER) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fer Tyrosine Kinase (FER) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fer Tyrosine Kinase (FER) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fer Tyrosine Kinase (FER) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fer Tyrosine Kinase (FER) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fer Tyrosine Kinase (FER) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fer Tyrosine Kinase (FER) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fer Tyrosine Kinase (FER) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fer Tyrosine Kinase (FER) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fer Tyrosine Kinase (FER) ELISA Kit Customized Service Offer
  1. "Isolation and sequence analysis of a novel human tyrosine kinase gene."Mol. Cell. Biol. 9:1587-1593(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells."J. Biol. Chem. 287:6100-6112(2012) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes."Oncogene 8:3403-3410(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and chromosomal mapping of new human tyrosine kinase genes."Oncogene 5:277-282(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Nuclear and cytoplasmic location of the FER tyrosine kinase."Mol. Cell. Biol. 11:1180-1183(1991) [PubMed] [Europe PMC] [Abstract]
  8. "The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors."Mol. Cell. Biol. 15:4553-4561(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER."J. Biol. Chem. 273:23542-23548(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells."Mol. Biol. Cell 14:3553-3564(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription."Mol. Cell. Biol. 23:7391-7402(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis."J. Cell Biol. 172:269-279(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids."Dev. Dyn. 237:3882-3891(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes."Biochim. Biophys. Acta 1793:781-791(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity."Cell. Signal. 21:588-596(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth."Mol. Cancer Res. 7:142-155(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration."Sci. Signal. 2:RA52-RA52(2009) [PubMed] [Europe PMC] [Abstract]
  20. "FES kinases are required for oncogenic FLT3 signaling."Leukemia 24:721-728(2010) [PubMed] [Europe PMC] [Abstract]
  21. "FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB."Proc. Natl. Acad. Sci. U.S.A. 108:7968-7973(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of SH2 domain of proto-oncogene tyrosine-protein kinase FER from Homo sapiens, Northeast structural genomics consortium (NESG) target HR3461D."Submitted (AUG-2009) to the PDB data bank
  23. "Closing in on the biological functions of Fps/Fes and Fer."Nat. Rev. Mol. Cell Biol. 3:278-289(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients." Science 253:665-669(1991) [PubMed] [Europe PMC] [Abstract]
  25. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]