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Solute Carrier Family 1, Member 5 (SLC1A5)

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SLC1A5; AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC; Neutral Amino Acid Transporter B(0); Baboon M7 virus receptor; Sodium-dependent neutral amino acid transporter type 2

Solute Carrier Family 1, Member 5 (SLC1A5)
CCC E345
HGNC 10943
MGI 105305
PubMed 23213057
RGD 708512
UniProt Q15758
Wiki SLC1A5
A common cell surface receptor is used for cell entry by the RD114/simian type D retroviruses, which include the feline endogenous retrovirus RD114, all strains of simian immunosuppressive type D retroviruses, the avian reticuloendotheliosis group, including spleen necrosis virus, and baboon endogenous virus.
SLC1A5 also serves as a retrovirus receptor, and RDR shows specific transport of neutral amino acids. By radiation hybrid mapping, they localized the receptor to a 500-kb region on chromosome 19q13.3. Infection of cells with RD114/type D retroviruses resulted in an impaired amino acid transport, suggesting a mechanism for virus toxicity and immunosuppression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE345Hu01 Recombinant Solute Carrier Family 1, Member 5 (SLC1A5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE345Hu01 Polyclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) WB; IHC; ICC; IP.
MAE345Hu21 Monoclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) WB; IHC; ICC; IP.
Assay Kits SEE345Hu ELISA Kit for Solute Carrier Family 1, Member 5 (SLC1A5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 1, Member 5 (SLC1A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 1, Member 5 (SLC1A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 1, Member 5 (SLC1A5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 1, Member 5 (SLC1A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 1, Member 5 (SLC1A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 1, Member 5 (SLC1A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 1, Member 5 (SLC1A5) ELISA Kit Customized Service Offer
  1. "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line."J. Biol. Chem. 271:18657-18661(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter."Proc. Natl. Acad. Sci. U.S.A. 96:2129-2134(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses."J. Virol. 73:4470-4474(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons."J. Biol. Chem. 276:27221-27230(2001) [PubMed] [Europe PMC] [Abstract]
  8. "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor."J. Virol. 74:3321-3329(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "A novel human endogenous retroviral protein inhibits cell-cell fusion."Sci. Rep. 3:1462-1462(2013) [PubMed] [Europe PMC] [Abstract]