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Alanine/Serine/Cysteine/Threonine Transporter (ASCT1)

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SLC1A4; SATT; Neutral Amino Acid Transporter A; Solute Carrier Family 1 Member 4,Glutamate/Neutral Amino Acid Transporter

Alanine/Serine/Cysteine/Threonine Transporter (ASCT1)
CCC E344
HGNC 10942
MGI 2135601
PubMed 7896285
RGD 735146
UniProt P43007
Wiki SLC1A4
In a screening for cDNAs encoding proteins similar to the sodium-coupled glutamate transporter GLAST1, Hofmann et al. isolated a cDNA clone encoding a protein that turned out to be identical to the neutral amino acid transporter ASCT1. The member of the GLAST-related transporter family did not transport glutamate or aspartate but alanine, serine, cysteine, and threonine instead. The open reading frame of 1,572 basepairs encodes 524 amino acid residues distributed over 8 exons spanning at least 40 kb of genomic DNA. The gene for ASCT1, designated SLC1A4, was assigned to 2p15-p13 by fluorescence in situ hybridization. The gene structure was not related to any previously characterized transporter gene. Transport is associated with a chloride channel activity that is thermodynamically uncoupled from amino acid transport.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanine/Serine/Cysteine/Threonine Transporter (ASCT1) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family."J. Biol. Chem. 268:15329-15332(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters."J. Biol. Chem. 268:15351-15355(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15."Genomics 24:20-26(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
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  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]