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Ras Homolog Gene Family, Member T2 (RHOT2)

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ARHT2; MIRO-2; RASL; Mitochondrial Rho GTPase 2

Ras Homolog Gene Family, Member T2 (RHOT2)
CCC E327
HGNC 21169
MGI 2384892
PubMed 22078885
RGD 727970
UniProt Q8IXI1
Wiki RHOT2
RHOT2 belongs to the mitochondrial Rho GTPase family. Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants. Three members of the family have been studied a great deal: Cdc42, Rac1, and RhoA. Rho proteins have been described as "molecular switches" and play a role in cell proliferation, apoptosis, gene expression, and multiple other common cellular functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member T2 (RHOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member T2 (RHOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member T2 (RHOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member T2 (RHOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member T2 (RHOT2) ELISA Kit Customized Service Offer
  1. "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis."J. Biol. Chem. 278:6495-6502(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase."Cytogenet. Genome Res. 106:91-97(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Rho GTPases have diverse effects on the organization of the actin filament system."Biochem. J. 377:327-337(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."Biochem. Biophys. Res. Commun. 344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
  9. "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."J. Cell Biol. 185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]