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Ras Homolog Gene Family, Member T1 (RHOT1)

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ARHT1; MIRO-1; Rac-GTP-binding protein-like protein; Mitochondrial Rho GTPase 1

Ras Homolog Gene Family, Member T1 (RHOT1)
CCC E326
HGNC 21168
MGI 1926078
PubMed 22860091
UniProt Q8IXI2
Wiki RHOT1
RHOT1 belongs to the mitochondrial Rho GTPase family.Expressed at high level in heart and skeletal muscle.Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules. The Rho family of GTPases is a family of small (~21 kDa) signaling G protein (more specific, a GTPase), and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants. Three members of the family have been studied a great deal: Cdc42, Rac1, and RhoA. Rho proteins have been described as "molecular switches" and play a role in cell proliferation, apoptosis, gene expression, and multiple other common cellular functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE326Hu01 Recombinant Ras Homolog Gene Family, Member T1 (RHOT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member T1 (RHOT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member T1 (RHOT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member T1 (RHOT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member T1 (RHOT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member T1 (RHOT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member T1 (RHOT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member T1 (RHOT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member T1 (RHOT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member T1 (RHOT1) ELISA Kit Customized Service Offer
  1. "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse."Genes Chromosomes Cancer 37:111-120(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis."J. Biol. Chem. 278:6495-6502(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Rho GTPases have diverse effects on the organization of the actin filament system."Biochem. J. 377:327-337(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."Biochem. Biophys. Res. Commun. 344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
  9. "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."J. Cell Biol. 185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy."Nature 510:370-375(2014) [PubMed] [Europe PMC] [Abstract]