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Chimerin 1 (CHN1)

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CHN; DURS2; RhoGAP2; ARHGAP2; NC; N-Chimerin; Chimaerin; A-chimaerin; Alpha-chimerin; GTPase-Activating Protein,Rho 2; Duane Retraction Syndrome 2

Chimerin 1 (CHN1)
CCC E318
HGNC 1943
MGI 1915674
PubMed 17719550
RGD 620139
UniProt P15882
Wiki Chimerin_1
Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may be involved in signal transduction.
This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding.Also known as alpha-1-chimerin, n-chimerin is a brain GTPase-activating protein (GAP) for the RAS-related p21 (RAC). Hall et al. (1993) found another form of chimerin, termed alpha-2-chimerin, and showed that it is the product of an alternately spliced transcript of the human n-chimerin gene. The mRNAs corresponding to the 2 forms of chimerin were expressed differently.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE318Hu01 Recombinant Chimerin 1 (CHN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE318Hu01 Polyclonal Antibody to Chimerin 1 (CHN1) WB; IHC; ICC; IP.
Assay Kits SEE318Hu ELISA Kit for Chimerin 1 (CHN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chimerin 1 (CHN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chimerin 1 (CHN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chimerin 1 (CHN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chimerin 1 (CHN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chimerin 1 (CHN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chimerin 1 (CHN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chimerin 1 (CHN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chimerin 1 (CHN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chimerin 1 (CHN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chimerin 1 (CHN1) ELISA Kit Customized Service Offer
  1. "Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene."J. Mol. Biol. 211:11-16(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence."Biochem. J. 287:415-422(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes."Mol. Cell. Biol. 13:4986-4998(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac."Eur. J. Biochem. 227:636-646(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor."Biochem. J. 272:767-773(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human chimerin 1 (CHN1)."Submitted (JUL-2011) to the PDB data bank
  11. "Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome." Science 321:839-843(2008) [PubMed] [Europe PMC] [Abstract]