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GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1)

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G3BP; HDH-VIII; ATP-dependent DNA helicase VIII; GAP SH3 domain-binding protein 1

GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1)
CCC E282
HGNC 30292
MGI 1351465
PubMed 21652632
RGD 621140
UniProt Q13283
Wiki G3BP1
G3BP contains an acid-rich amino acid domain between amino acids 144 and 221, followed by 2 consensus RNA-binding motifs and several C-terminal arg/gly-rich boxes, which are also implicated in RNA binding. Northern blot analysis detected a 3.3-kb G3BP transcript in all fetal and adult tissues examined, with prominent expression in adult skeletal muscle. Immunofluorescence analysis of several mammalian cell lines localized G3BP within the cytoplasm. The staining intensity varied between cells, but the intensity and localization were unaltered under various experimental conditions. G3bp purified from Chinese hamster lung fibroblasts and recombinant G3BP expressed in insect cells both showed apparent molecular masses of 68 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein SH3 Domain Binding Protein 1 (G3BP1) ELISA Kit Customized Service Offer
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  6. , Submitted (DEC-2008) to UniProtKB
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  8. "RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization."Mol. Cell. Biol. 21:7747-7760(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease."Oncogene 20:3869-3879(2001) [PubMed] [Europe PMC] [Abstract]
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  11. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
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  14. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells."Cell 154:859-874(2013) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the NTF2 domain of ras GTPase-activating protein-binding protein 1."Submitted (FEB-2011) to the PDB data bank