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3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO)

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HAD; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase

3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO)
CCC E249
HGNC 4796
MGI 1349444
PubMed 20211485
RGD 71071
UniProt P46952
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system.
HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxyanthranilate-3,4-Dioxygenase (HAAO) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase."J. Biol. Chem. 269:13792-13797(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase."Submitted (AUG-2007) to the PDB data bank