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RAN Binding Protein 2 (RANBP2)

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p270; NUP358; E3 SUMO-protein ligase RanBP2; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358

RAN Binding Protein 2 (RANBP2)
CCC E238
HGNC 9848
MGI 894323
PubMed 19118815
RGD 1560047
UniProt P49792
Wiki RANBP2
RanBP2 is also known as Nup358 since it is a member nucleoporin family that makes-up the nuclear pore complex. RanBP2 has a 358 KDa molecular weight.The RanBP2 gene encodes a very large RAN-binding protein that localizes to cytoplasmic filaments emanating from the nuclear pore complex. RanBP2/Nup358 is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in controlling selective processes of the the Ran-GTPase cycle. RanBP2 is composed of multiple domains. Each domain of RanBP2 selectively and directly interacts with distinct proteins such as Ran GTPase, importin-beta, exportin-1/CRM1, red opsin, subunits of the proteasome, cox11 and the kinesin-1 isoforms, KIF5B and KIF5C. Another partner of RanBP2 is the E2 enzyme UBC9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 2 (RANBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 2 (RANBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 2 (RANBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 2 (RANBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 2 (RANBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 2 (RANBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 2 (RANBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 2 (RANBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 2 (RANBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 2 (RANBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 2 (RANBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 2 (RANBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 2 (RANBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 2 (RANBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 2 (RANBP2) ELISA Kit Customized Service Offer
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  2. "A giant nucleopore protein that binds Ran/TC4."Nature 376:184-188(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif."Proc. Natl. Acad. Sci. U.S.A. 92:3328-3332(1995) [PubMed] [Europe PMC] [Abstract]
  5. "The nucleoporin RanBP2 has SUMO1 E3 ligase activity."Cell 108:109-120(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export."J. Cell Biol. 156:617-630(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type."Nat. Struct. Mol. Biol. 11:984-991(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a SUMO-binding motif that recognizes SUMO-modified proteins."Proc. Natl. Acad. Sci. U.S.A. 101:14373-14378(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection."Nat. Struct. Mol. Biol. 12:67-74(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers."Arch. Biochem. Biophys. 453:70-74(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Parkin ubiquitinates and promotes the degradation of RanBP2."J. Biol. Chem. 281:3595-3603(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin."Mol. Biol. Cell 20:410-418(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport."Nature 398:39-46(1999) [PubMed] [Europe PMC] [Abstract]
  28. "Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran."J. Mol. Biol. 348:711-725(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex."Nature 435:687-692(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2."J. Biol. Chem. 287:4740-4751(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Crystal structure of the N-terminal domain of Nup358/RanBP2."J. Mol. Biol. 423:752-765(2012) [PubMed] [Europe PMC] [Abstract]
  32. "Structural and functional analysis of the C-terminal domain of Nup358/RanBP2."J. Mol. Biol. 425:1318-1329(2013) [PubMed] [Europe PMC] [Abstract]
  33. "Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2." Am. J. Hum. Genet. 84:44-51(2009) [PubMed] [Europe PMC] [Abstract]