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XIAP Associated Factor 1 (XAF1)

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BIRC4BP; HSXIAPAF1; XIAPAF1; BIRC4-binding protein

XIAP Associated Factor 1 (XAF1)
CCC E230
HGNC 30932
MGI 3505735
PubMed 11175744
UniProt Q6GPH4
Wiki XAF1
X-linked inhibitor of apoptosis (XIAP) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases. XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells.
The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant XIAP Associated Factor 1 (XAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to XIAP Associated Factor 1 (XAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to XIAP Associated Factor 1 (XAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for XIAP Associated Factor 1 (XAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for XIAP Associated Factor 1 (XAF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant XIAP Associated Factor 1 (XAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to XIAP Associated Factor 1 (XAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to XIAP Associated Factor 1 (XAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for XIAP Associated Factor 1 (XAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for XIAP Associated Factor 1 (XAF1) ELISA Kit Customized Service Offer
  1. "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity."Nat. Cell Biol. 3:128-133(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses."Gastroenterology 132:2459-2477(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis."J. Biol. Chem. 277:28504-28511(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1."Biochem. Biophys. Res. Commun. 339:1148-1154(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP."Mol. Cell. Biochem. 286:67-76(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex."J. Biol. Chem. 282:26202-26209(2007) [PubMed] [Europe PMC] [Abstract]
  10. "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway."J. Biol. Chem. 282:13059-13072(2007) [PubMed] [Europe PMC] [Abstract]
  11. "ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."Cell Death Differ. 20:1055-1067(2013) [PubMed] [Europe PMC] [Abstract]