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Alkylglycerone Phosphate Synthase (AGPS)

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ADHAPS; ADAS; ALDHPSY; ADPS; ADAP-S; Aging-associated gene 5 protein; Alkyldihydroxyacetonephosphate synthase, peroxisomal

Alkylglycerone Phosphate Synthase (AGPS)
CCC E168
HGNC 327
MGI 2443065
PubMed 3707712
RGD 620364
UniProt O00116
Wiki AGPS
Alkylglycerone Phosphate Synthase is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alkylglycerone Phosphate Synthase (AGPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alkylglycerone Phosphate Synthase (AGPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkylglycerone Phosphate Synthase (AGPS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alkylglycerone Phosphate Synthase (AGPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alkylglycerone Phosphate Synthase (AGPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkylglycerone Phosphate Synthase (AGPS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alkylglycerone Phosphate Synthase (AGPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alkylglycerone Phosphate Synthase (AGPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alkylglycerone Phosphate Synthase (AGPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkylglycerone Phosphate Synthase (AGPS) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of human alkyl-dihydroxyacetonephosphate synthase cDNA reveals the presence of a peroxisomal targeting signal 2."Biochim. Biophys. Acta 1346:25-29(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency."J. Biol. Chem. 273:10296-10301(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Impaired membrane traffic in defective ether lipid biosynthesis."Hum. Mol. Genet. 10:127-136(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3."Hum. Mutat. 33:189-197(2012) [PubMed] [Europe PMC] [Abstract]