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Defensin Alpha 3, Neutrophil Specific (DEFa3)

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HNP3; DEF3; HNP-2; Neutrophil defensin 2

Defensin Alpha 3, Neutrophil Specific (DEFa3)
CCC E135
HGNC 2762
PubMed 20502117
UniProt P59666
Wiki DEFA3
DEFA1 and DEFA3 differ from each other only by their N-terminal amino acids (ala and asp, respectively). DEFA2 is identical to both except that it lacks this N-terminal amino acid.DEFA1-, DEFA2-, and DEFA3-specific antibodies depleted antiviral activity in a dose-dependent manner, particularly against viruses using CXCR4 rather than CCR5 as a coreceptor. Addition of synthetic or purified natural defensins inhibited HIV-1 replication in vitro.
Flow cytometric analysis determined that in addition to neutrophils, a small population of CD8-positive T lymphocytes harbor and secrete DEFA1, DEFA2, and DEFA3. Zhang et al. (2002) proposed that these defensins account for much of the anti-HIV-1 activity of CAF that is not attributable to beta chemokines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE135Hu01 Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3) Positive Control; Immunogen; SDS-PAGE; WB.
RPE135Hu02 Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE135Hu01 Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) WB; IHC; ICC; IP.
LAE135Hu71 Biotin-Linked Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) WB; IHC; ICC.
LAE135Hu81 FITC-Linked Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) WB; IHC; ICC; IF.
PAE135Hu02 Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) WB,IHC
Assay Kits SEE135Hu ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCE135Hu CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE135Mu01 Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE135Mu01 Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) WB; IHC; ICC; IP.
Assay Kits SEE135Mu ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of human defensin cDNA clones."Proc. Natl. Acad. Sci. U.S.A. 85:7327-7331(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Differentiation stage-specific expression of a gene during granulopoiesis."Leukemia 3:227-234(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The structure of neutrophil defensin genes."FEBS Lett. 321:267-273(1993) [PubMed] [Europe PMC] [Abstract]
  4. ErratumFEBS Lett. 326:299-300(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Primary structures of three human neutrophil defensins."J. Clin. Invest. 76:1436-1439(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide."J. Biol. Chem. 264:4003-4007(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Posttranslational processing of defensins in immature human myeloid cells."Blood 79:1538-1544(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Antibacterial activity and specificity of the six human alpha-defensins."Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization."Science 251:1481-1485(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids."J. Biol. Chem. 280:32921-32929(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs."J. Biol. Chem. 282:19653-19665(2007) [PubMed] [Europe PMC] [Abstract]