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Ephrin Type A Receptor 3 (EPHA3)

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ETK; ETK1; HEK; HEK4; TYRO4; Human embryo kinase; Tyrosine-protein kinase receptor ETK1

Ephrin Type A Receptor 3 (EPHA3)
CCC E123
HGNC 3387
MGI 99612
PubMed 23410976
RGD 68389
UniProt P29320
Wiki EPHA3
EPH receptor A3 (ephrin type-A receptor 3) is a protein belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.
The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE123Hu01 Recombinant Ephrin Type A Receptor 3 (EPHA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE123Hu21 Monoclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) WB; IHC; ICC; IP.
PAE123Hu01 Polyclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) WB; IHC; ICC; IP.
Assay Kits SEE123Hu ELISA Kit for Ephrin Type A Receptor 3 (EPHA3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 3 (EPHA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 3 (EPHA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 3 (EPHA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 3 (EPHA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 3 (EPHA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 3 (EPHA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 3 (EPHA3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines."Proc. Natl. Acad. Sci. U.S.A. 89:1611-1615(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules."Cancer Res. 60:4855-4863(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line."J. Biol. Chem. 267:3262-3267(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling."J. Cell Sci. 115:1059-1072(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen."J. Biol. Chem. 279:9522-9531(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."Cell 123:291-304(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3."J. Biol. Chem. 280:26526-26532(2005) [PubMed] [Europe PMC] [Abstract]
  9. "PTP1B regulates Eph receptor function and trafficking."J. Cell Biol. 191:1189-1203(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3)."Structure 16:873-884(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers."Hum. Mutat. 27:1060-1061(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas."PLoS ONE 5:E12653-E12653(2010) [PubMed] [Europe PMC] [Abstract]