Ephrin Type B Receptor 2 (EPHB2)

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CAPB; DRT; EPHT3; ERK; Hek5; PCBC; Tyro5; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH-like kinase 5; EPH tyrosine kinase 3

Ephrin Type B Receptor 2 (EPHB2)
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins.
The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EPHB2 is a receptor for ephrin-B family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE117Hu01 Recombinant Ephrin Type B Receptor 2 (EPHB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE117Hu02 Recombinant Ephrin Type B Receptor 2 (EPHB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 2 (EPHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 2 (EPHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer
  1. "Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors."Cancer Res. 54:3645-3650(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family."Hum. Mol. Genet. 4:2033-2045(1995) [PubMed] [Europe PMC] [Abstract]
  3. "A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals."Oncogene 17:521-526(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases."Oncogene 10:897-905(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the human ERK gene as a putative receptor tyrosine kinase and its chromosomal localization to 1p36.1: a comparative mapping of human, mouse, and rat chromosomes."Genomics 26:382-384(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer."Biochem. Biophys. Res. Commun. 194:698-705(1993) [PubMed] [Europe PMC] [Abstract]
  8. "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases."Oncogene 6:1057-1061(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Oligomeric structure of the human EphB2 receptor SAM domain."Science 283:833-836(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition."J. Biol. Chem. 282:36505-36513(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer." Nat. Genet. 36:979-983(2004) [PubMed] [Europe PMC] [Abstract]
  16. "A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history."J. Med. Genet. 43:507-511(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]