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Ephrin Type B Receptor 1 (EPHB1)

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NET; ELK; EPHT2; Hek6; EPH tyrosine kinase 2; EPH-like kinase 6; Neuronally-expressed EPH-related tyrosine kinase; Tyrosine-protein kinase receptor EPH-2

Ephrin Type B Receptor 1 (EPHB1)
CCC E116
HGNC 3392
MGI 1096337
PubMed 22103419
RGD 2556
UniProt P54762
Wiki EPHB1
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins.
The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EPHB1 is a receptor for ephrin-B family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 1 (EPHB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 1 (EPHB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 1 (EPHB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 1 (EPHB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 1 (EPHB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 1 (EPHB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 1 (EPHB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 1 (EPHB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 1 (EPHB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 1 (EPHB1) ELISA Kit Customized Service Offer
  1. "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain."Genomics 29:426-437(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase."J. Biol. Chem. 273:1303-1308(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells."J. Biol. Chem. 271:23588-23593(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses."Genes Dev. 12:667-678(1998) [PubMed] [Europe PMC] [Abstract]
  11. "The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1."J. Biol. Chem. 277:3823-3828(2002) [PubMed] [Europe PMC] [Abstract]
  12. "EphB1 associates with Grb7 and regulates cell migration."J. Biol. Chem. 277:45655-45661(2002) [PubMed] [Europe PMC] [Abstract]
  13. "EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis."J. Cell Biol. 162:661-671(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway."Traffic 9:251-266(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the C-terminal SAM-domain of mouse ephrin type-B receptor 1 precursor (EC 2.7.1.112)."Submitted (JUL-2007) to the PDB data bank
  16. "Solution structures of the FN3 domain of human ephrin type-B receptor 1."Submitted (FEB-2009) to the PDB data bank
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]